Konohamaru named after the village he lives in: Konoha, is the grandson of the Third Hokage and by extension the nephew of Asuma Sarutobi. Konohamaru usually hangs out with his two friends, Udon and Moegi. Together, they call themselves the "Konohamaru Corps" ("Konohamaru Ninja Squad" in the English dub).

In Part II they are teamed together under the leadership of Ebisu, Konohamaru's former tutor. At the start of the series, Konohamaru feels unacknowledged due to his status as the Hokage's grandson. As such, he frequently attempts to defeat his grandfather in battle so that he can become Hokage himself and earn the recognition he desires. Once meeting Naruto Uzumaki, Konohamaru realizes that he can't become Hokage by simply attacking his grandfather and will need to train hard to accomplish this goal.